Cunningham Group - Selected Publications

  • Herpin A, Lelong C, Becker TS, Rosa F, Favrel P, Cunningham C (2005). Structural and functional evidence for a singular repertoire of BMP receptor signal transducing proteins in the lophotrochozoan Crassostrea gigas suggests a shared ancestral BMP/activin pathway. FEBS J. 272(13):3424-40.


  • Herpin A, Lelong C, Becker T, Rosa FM, Favrel P, Cunningham C (2005). Structural and functional evidences for a type 1 TGF-ß sensu stricto receptor in the lophotrochozoan Crassostreagigas suggest conserved molecular mechanisms controlling mesodermal patterning across bilateria. Mech Dev.122(5):695-705.


  • Stansberg C, Subramaniam S, Collet B, Secombes CJ, Cunningham C (2005). Cloning of the Atlantic Salmon (salmo salar) IL-1 receptor associated protein. Fish Shellfish Immunology, 19:53-65.


  • Sumathi Subramaniam S, Stansberg C, Cunningham C (2004). The interleukin 1 receptor family Dev. Comp. Immunol. (review) 28(10): 415-428.


  • Stansberg C, Subramaniam S, Olsen L, Secombes CJ & Cunningham C (2003) Cloning and characterisation of a putative ST2L homologue from Atlantic salmon (Salmo salar). Fish Shellfish Immunology, 15:211-224.


  • Cupit PM, Hansen JD, McCarty AS, White G, Chioda M, Spada F, Smale ST & Cunningham C (2003) Ikaros family members from the agnathan Myxine glutinosa and the urochordate Oikopleura dioica: emergence of an essential transcription factor for adaptive immunity. J. Immunol 171:6006-6013.


  • Wang T, Zou J, Cunningham C & Secombes CJ (2002) Cloning and functional characterisation of the interleukin-1 beta 1 promoter of rainbow trout (Oncorhynchus mykiss). Biochimie Biophysica Acta 1575(1-3):108-16.


  • Bird S, Wang T, Zou J, Cunningham C & Secombes CJ (2002) The first cytokine sequence within cartilaginous fish: IL-1 beta in the small spotted catshark (Scyliorhinus canicula). J. Immunol 168:3329-40.


  • Subramaniam S, Stansberg C, Olsen L, Zou J, Secombes CJ & Cunningham C (2002) Cloning of a Salmo salar interleukin-1 receptor-like cDNA. Dev Comp Immunol 26(5):415-31.


  • Herpin A, Favrel P & Cunningham C (2002). Gene structure and expression of cg-ALR1, a type I activin-like receptor from the bivalve mollusc Crassostrea gigas. Gene 301:21-30.


  • Laing KJ, Holland J, Bonilla S, Cunningham C & Secombes C (2001) Cloning and sequencing of caspase 6 in rainbow trout, Oncorhynchus mykiss, and analysis of its expression under conditions known to induce apoptosis. Dev Comp Immunol 25:303-12.


  • Hong S, Zou J, Crampe M, Peddie S, Scapigliatti G, Bols N, Cunningham C & Secombes CJ (2001) The production and bioactivity of rainbow trout (Oncorhynchus mykiss) recombinant IL-1 beta. Vet Immunol and Immunopath. 81(1-2):1-14.


  • Peddie S, Zou J, Cunningham C, Secombes CJ (2001) Rainbow trout (Oncorhynchus mykiss) recombinant IL-1beta and derived peptides induce migration of head-kidney leucocytes in vitro. Fish and Shellfish Immunology 11:697-709.


  • Cupit PM, Lorenzen N, Strachan G, Kemp GJL, Secombes CJ. & Cunningham C (2001) Neutralisation and binding of VHS virus by monovalent antibody fragments. Virus Research 81:47-56.


  • Lorenzen N, Cupit PM, Secombes CJ & Cunningham C (2000) Three monoclonal antibodies to the VHS virus glycoprotein: comparison of reactivity in relation to differences in immunoglobulin variable domain gene sequences. Fish and Shellfish Immunology 10:129-142.


  • Zou J, Holland J, Pleguezuelos O, Cunningham C & Secombes CJ (2000). Factors influencing the expression of interleukin-1 beta in cultured rainbow trout (Oncorhynchus mykiss) leucocytes. Dev Comp Immunol. 24:575-582.


  • Laing KJ, Cunningham C & Secombes CJ (2000) Genes for three different isoforms of transforming growth factor ? are present in plaice DNA. Fish and Shellfish Immunology 10:261-271.


  • Zou J, Bird S, Minter R, Horton J, Cunningham C & Secombes CJ (2000) Molecular cloning of the gene for interleukin-1beta from Xenopus laevis and analysis of expression in vivo and in vitro. Immunogenetics 51(4-5):332-8.


  • Pleguezuelos O, Zou J, Cunningham C & Secombes CJ (2000) Cloning, sequencing, and analysis of expression of a second IL-1beta gene in rainbow trout (Oncorhynchus mykiss). Immunogenetics 51:1002-11.


  • Lorenzen N, Cupit PM, Einer-Jensen K, Lorenzen E, Ahrens P, Secombes CJ & Cunningham C (2000) Immunoprophylaxix in fish by injection of mouse antibody genes. Nature Biotechnology 18:1177-1180.


  • Zou J, Cunningham C & Secombes CJ (1999) The rainbow trout Oncorhynchus mykiss interleukin-1 beta gene has a differ organization to mammals and undergoes incomplete splicing. Eur J Biochem 259:901-908.


  • Zou J, Grabowski PS, Cunningham C & Secombes CJ (1999) Molecular cloning of interleukin 1beta from rainbow trout Oncorhynchus mykiss reveals no evidence of an ice cut site. Cytokine 11:552-560.


  • Laing KJ, Pilstrom L, Cunningham C & Secombes CJ (1999) TGF-beta3 exists in bony fish.Vet Immunol Immunopathol. 72:45-53.


  • Daniels GD, Zou J, Charlemagne J, Cunningham C & Secombes CJ (1999) Cloning of two chemokine receptor homologs (CXC-R4 and CC-R7) in rainbow trout Oncorhynchus mykiss. Journal of Leukocyte Biology 65:684-690.


  • Zou J, Neumann NF, Holland JW, Belosevic M, Cunningham C, Secombes CJ & Rowley AF (1999) Fish macrophages express a cyclooxygenase-2 homologue following activation. Biochemal Journal 340:153-159.


  • Secombes CJ, Zou J, Laing K, Daniels GD & Cunningham C (1999) Cytokine genes in fish. Aquaculture 172, 93-102.


  • Hardie LJ, Laing KJ, Daniels GD, Grabowski PS, Cunningham C & Secombes CJ (1998) Isolation of the first piscine transforming growth factor b gene: analysis reveals tissue specific expression and a potential regulatory sequence in Rainbow Trout (Oncorhynchus mykiss). Cytokine 10, 555-563.


  • Secombes CJ, Zou J, Daniels G, Cunningham C, Koussounadis A & Kemp G (1998). Rainbow trout cytokine and cytokine receptor genes. Immunological Reviews 166, 333-340.